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KMID : 1189420210340020001
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2021 Volume.34 No. 2 p.1 ~ p.20
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Studies on Skin Anti-aging Efficacy of Hydrolysate from Phellinus igniarius
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Kim Tae-Jun
Kwak Byeong-Mun
Kim Hee-Taek
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Abstract
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Objective : The object of this study was to assess the efficacy of hydrolysate from Phellinus igniarius(HPI) on anti-aging activities in vitro measurement and mini clinical study performed on 5 subjects.
Methods : To evaluate skin anti-aging efficacy of HPI, 1,1-diphenyl-2-picrylhydrazyl(DPPH) radical scavenging activity, type I collagen synthesis, inhibition of nitric oxide(NO) production, inhibiton of tyrosinase, hyaluronan synthase(HAS)2, 3 mRNA expression were measured in vitro. Also, mini clinical study of skin hydration was performed on 5 subjects using HPI in distilled water(DW) and 1,3-butylene glycol diluted solution(30% in DW).
Results : 1. DPPH radical scavenging activity of HPI was increased in a dose-dependant. 2. TypeⅠ collagen synthesis was increased in 50, 100 and 500㎍/㎖ of HPI. 3. NO production was not inhibited in all concentrations of HPI. 4. Tyrosinase was inhibited in 500, 1000, 2500 and 5000㎍/㎖ of HPI. 5. HAS2 mRNA expression was increased in 50, 100, 150 and 200㎍/㎖ of HPI, HAS3 mRNA expression was increased in 100, 150, and 200㎍/㎖ of HPI. 6. In the mini clinical study of 5 subjects, there was a difference in skin hydration over time for each solutions, but it was not statistically siginificant.
Conclusions : HPI increased DPPH radical scavenging activity, type I collagen synthesis, and HAS2, HAS3 mRNA expression. HPI also suppressed tyrosinase. The findings of this study suggest that HPI can be used as an skin anti-aging material.
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KEYWORD
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Hydrolysate from Phellinus igniarius(HPI), Anti-aging, Antioxidant, Whitening, Moisturizing
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